Accuracy of TOXYScreen Test Results

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Evaluating Oral Fluid as a Screening Tool for Lead Poisoning

Corresponding author: Anil T. Mangla MS, PhD, MPH

Chief Epidemiologist
Georgia Lead Poisoning Prevention Programs
2 Peachtree Street, Ste 13-101
Atlanta, GA 30303

Abstract introduction to Oral Fluid Screening:

Lead is present in the oral fluid of lead-exposed individuals.  The significant correlations reported with blood lead suggest that oral fluid may be a valuable tool for assessing lead exposure25-28.

In humans, oral fluid is produced from the parotid, sublingual and the submandibular29 glands “Oral fluid”, as used here, refers to the liquid normally present in the region of the oral cavity anterior to the teeth and gum line.

While oral fluids usually contain some saliva, only relatively small amounts of the secretions of the oral fluid glands are present.  The small amount of saliva is, in oral fluid, mixed with gingival crevicular fluid and other secretions from the mucosal surfaces of the cheek and gums.

Thus, oral fluid is more similar to an ultra-filtrate of the plasma than common saliva. Depending on the method employed to collect the oral fluid as well as the oral health of the subject from whom the sample is gathered, a sample may contain cells from the collection site and even small amounts of blood (including both blood cells and plasma).